Slience, Active Ingredients
    • PhytoCellTec™ Malus Domestica A high-tech biotechnology to cultivate cells from rare plants.

      Mibelle Biochemistry developed a novel technology (PCT) enabling the cultivation of cells from rare and endangered plant species. This PCT technology, based on the unique totipotency of plant cells uses the wound healing mechanism of plants. A part of a plant is wounded to induce the formation of callus cells. This wound healing tissue consists of dedifferentiated cells which are stem cells. Callus cells are harvested and cultivated in a suspension and a novel bioreactor system enables a large scale culture. To obtain the PhytoCellTec™ Malus Domestica cosmetic ingredient, these stem cells are harvested and homogenized at 1200 bar together with liposomes to encapsulate and stabilize oil- and water soluble components.

      Advantages of PhytoCellTec™ Technology
      This innovative technology developed by Mibelle Biochemistry offers the following advantages:
      - Possibility to cultivate cells of rare and endangered plants while respecting the environment
      - Availability of plant material independent of the season and market’s demand
      - Plant material completely free of environmental pollutants and pesticides
      - Constant concentrations of metabolites in the stem cells
    • Oligopeptide-1 – Epidermal Growth Factor Epidermal growth factor or EGF is a low-molecular-weight polypeptide composed of 53 amino acids that plays an important role in the regulation of cell growth, proliferation and differentiation.

      Stanley Cohen of Vanderbilt University, who was the first to discover the EGF, won the Nobel Prize in Physiology and Medicine in 1986, but it was Greg Brown who patented EGF for cosmetic use in 1989.

      EGF can accelerate the growth of the epidermal cells, nervous cells and epithelial cells on organ tissues. h-EGF is an important ingredient of anti-wrinkle and anti-aging cosmetics.

      EGF has been demonstrated to:
      - Stimulate the growth and proliferation of skin, cornea and tracheal epithelium tissue in vivo.
      - Accelerate the healing process of epidermis damage on skin, cornea, etc.
      - Accelerate the proliferation of epithelial cells in human and animals.
      - Facilitate the biosynthesis of protein, RNA, DNA as well as metabolic activity in epidermal cells.
      - Reduce and prevent lines and wrinkles by actively generating new skin cells.
      - Whiten skin tones with full of vitality and energy.
      - Eliminate scars on skin by forming new skin cells.
    • Trylagen The triple action skin plumping treatment that works in just 7 days! MirApple contains the breakthrough skin plumper, Trylagen. Scientifically proven to almost triple the appearance of collagen in just 7 days! The triple action helps boost the appearance of collagen, keep collagen looking uniform and helps protect collagen from degenerating. The result? Skin appears firmer, smoother and wrinkles appear to ‘fill out’ becoming less and less visible!

      Trylagen, this revolutionary tri-functional ingredient is made up of a combination of active peptides and proteins which target the appearance of collagen in both young and mature skin.

      1. Collagen boosting
      In vitro studies of Trylagen showed astonishing results on the different types of collagen found in the skin. In one in vitro study collagen III was seen to almost triple (that’s 300%!) in just 7 days.

      2. Collagen organisation
      Trylagen was seen in in-vitro studies to promote uniformity in the dimensions of collagen bundles by regulating their diameter and spacing. This provides for better cohesion and stabilization of collagen fibres.

      3. Collagen Protection
      In vitro investigation revealed that Trylagen was able to influence the activity of the enzymes responsible for collagen breakdown. These studies showed SOD activity to be increased by 39%, collagenase was inhibited by 13.8% and metalloproteinase was inhibited by up to 73.9%.

      A major clinical study showed that a cream containing 5% Trylagen applied twice daily reduced wrinkle depth by up to 35.32% after 30 days.